The Beta-Lactamase Monoclonal Antibody from MyBioSource.com is a Mouse Monoclonal antibody to blaTEM-1. This antibody recognizes Bacteria/Archaea antigen. The Beta-Lactamase Monoclonal Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
The beta-lactam antibiotics (penicillins and cephalosporins) are the most frequently used antimicrobial agents. All of the beta-lactams are structurally related through the presence of a core beta-lactam ring. Bacterial resistance to beta-lactams continues to increase, primarily due to the production of betalactamases. Beta-lactamases catalyze the hydrolysis of the beta-lactam bond which destroys antibacterial activity. Bacteria that produce TEM- or SHVtype beta-lactamases have point mutations in structural genes that have extended the substrate specificity of these beta-lactamases. As a result, many of the beta-lactamase-producing Gram-negative pathogens have become multi-drug resistant